Given that 60% of Ukraine's population resides in urban areas, socio-economic and environmental modernization of the country's regions is indispensable for sustainable development. This study addresses the factors characterized by various challenges that impede the sustainable development of urbanized territories in Ukraine. The aim of this research is to analyze the conditions necessary for ensuring sustainable development, using the Odesa industrial-urban agglomeration as a case study. The methodological framework of this article relies on a critical analysis of existing assessments of the conditions for sustainable development in urbanized territories of Ukraine, alongside our own research findings on this issue. Preservation of a favorable natural environment and efficient resource utilization are fundamental principles underpinning the sustainable development of urbanized areas. To actualize these principles, a comprehensive set of measures is proposed to enhance the quality of the air basin, natural waters, soil cover, geological environment, and urban biocenosis. Additionally, an effective waste management system is advocated. Furthermore, strategies for conserving and expanding green spaces, which play a pivotal role in mitigating the adverse effects of urbanization on the environment, enhancing air quality, and improving the well-being of urban residents, are delineated. Horizontal and vertical landscaping initiatives further enhance the aesthetic appeal of the city.