Adsorption of 4-chlorophenol (4-CP) via Magnetite/SiO2/Xanthan were investigated using batch scale experiments. The study aims to prepare a green nanocomposite (NC) and determine whether it is effective in removing 4-CP. To synthesize NC (Fe3O4/SiO2/xanthan) from Alocasia macrorrhiza extract, a simple, and green method was applied. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) were used to identify the prepared NC. The Response Surface Modeling (RSM) was employed to optimize operational variables in the adsorption process of 4-chlorophenol (4-CP) from an aqueous solution using NCs as an adsorbent. The results indicate that the oxidation percentage of 4-CP is 89.47%, at ideal conditions (temperature (25 C°), 4-CP concentration (10 mg/L), contact time (180 minutes), rpm speed (200), pH (3), and adsorbent dose (1 g/L)). Moreover, the model's normal reaction results have a sensible likeness to the actual data (R2 = 95.19), exhibiting the productivity of this technique in making an exact forecast. A second-order polynomial multiple regression model was utilized to assess the responses, which affirms that it was a satisfactory adjustment (R2=0.9864) with the accomplished data through investigation of variance (R2 = 95.19%, R2 adj = 94.34% and R2 pred =93.24%).